Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction
Open Access
- 1 June 2006
- journal article
- Published by American Society of Hematology in Blood
- Vol. 107 (11) , 4257-4265
- https://doi.org/10.1182/blood-2005-10-4047
Abstract
The therapeutic potential of hematopoietic stem cell (HSC) gene therapy can be fully exploited only by reaching efficient gene transfer into HSCs witKeywords
This publication has 53 references indexed in Scilit:
- Inhibition of Lysosome and Proteasome Function Enhances Human Immunodeficiency Virus Type 1 InfectionJournal of Virology, 2005
- Cell Cycle Arrest in G 2 /M Promotes Early Steps of Infection by Human Immunodeficiency VirusJournal of Virology, 2005
- Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairmentBlood, 2004
- Quantification of Free Circulating DNA As a Diagnostic Marker in Lung CancerJournal of Clinical Oncology, 2003
- IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytesBlood, 2003
- Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID miceBlood, 2002
- Molecular Evidence of Lentiviral Vector-Mediated Gene Transfer into Human Self-Renewing, Multi-potent, Long-Term NOD/SCID Repopulating Hematopoietic CellsMolecular Therapy, 2002
- An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/β2-microglobulinnull miceExperimental Hematology, 2002
- Cell cycle distribution of cord blood-derived haematopoietic progenitor cells and their recruitment into the S-phase of the cell cycleBritish Journal of Haematology, 2000
- A Simple, One‐Step Clonal Assay Allows the Sequential Detection of Committed (CFU‐GM‐like) Progenitors and Several Subsets of Primitive (HPP‐CFC) Murine ProgenitorsThe International Journal of Cell Cloning, 1999