A Novel Approach to the Ergot Alkaloid Skeleton
- 1 January 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (01) , 27-28
- https://doi.org/10.1055/s-1995-4869
Abstract
We describe a ten stage synthesis of an advanced intermediate for elaboration into ergot alkaloids, from 4-carbomethoxyindole. The key step involved an intramolecular cyclisation involving the allyl cation derived from N-benzenesulphonyl, 3-(3’-methoxyprop-2’-en-1’-yl), 4-(1’-hydroxy-2’-trimethylsilylmethyl-prop-2’-en-1’-yl)-indole.Keywords
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