Budesonide Enemas for Topical Therapy of Ulcerative Colitis

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Abstract
Budesonide is a nonhalogenated glucocorticosteroid that is very suitable for topical therapy in left-sided colitis because it has a high ratio of topical to systemic activity. Although it is absorbed, it is very rapidly metabolized by the liver (first pass metabolism). It does not suppress the hypothalamic-pituitary axis. Budesonide has been shown to be more effective than placebo and predinsolone enemas for the treatment of left-sided ulcerative colitis.

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