Suppression of Plasma Androgen Levels with a Combination Therapy of Depot-Estrogen (TuristeronR) and DexamethasoneR in Patients with Prostatic Cancer
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 94 (06) , 239-243
- https://doi.org/10.1055/s-0029-1210905
Abstract
Treatment of patients with prostatic cancer with a combination of 1–2 mg depot-estrogen (ethinylestradiol sulfonate = TuristeronR) per week and 1 mg dexamethasone per day suppressed the mean testosterone (T) level to 2.8% (0.53 nmol/1), the free T to 0.8% (1.9 pmol/1) and the adrenal androgens (AA) — androstenedione (A), dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) — to more than 40% of the initial values. Treatment with Turisteron alone (2 mg per week) did not change the DHEA and DHEAS levels but decreased plasma A concentration to 65% (2.96 nmol/1) of the initial values.Keywords
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