Antibody against Serum-Hepatitis Antigen

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Abstract
The passive hemagglutination method was used to evaluate serum-hepatitis (SH, Australia/ HAA) antibody content of conventional, "convalescent" and hyperimmune gamma-globulin preparations. SH antibody was detected at low titer in most batches of conventional gamma globulin (less than 1:2 to 1:64), in contrast to a titer of 1:512,000 in gamma globulin prepared from hemophilic plasma containing known precipitating antibody ("SH immune globulin"). Injection of "SH immune globulin" resulted in the appearance of SH antibody that remained detectable for at least two months in the blood of half of the recipients.