GROWTH PATTERNS OF ULTRAVIOLET LIGHT-INDUCED FIBROSARCOMAS IN SUBCUTANEOUS, PERITONEAL, AND VASCULAR COMPARTMENTS OF SYNGENEIC RECIPIENTS

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Abstract
The percentage of tumor-bearing mice did not differ following s.c., i.p. or i.v. injection of tumor cells. The time of death of the tumor-bearing animals varied according to the route of tumor cell injection. This could be attributable to a combination of factors, including tumor growth rate at the site of implantation, survival of injected tumor cells, accessibility of the tumor to immunological destruction and the physiological necessity of the tissue replaced by the expanding tumor volume. Although in some tumor systems the route of injection is an important factor in tumor growth, this was not the case for the UV-induced fibrosarcomas studied here. The possibility raised by Paget that some tissues may provide a better soil than others for the growth of a particular tumor was not substantiated by this study. It may be that the growth of these tumors of relatively high antigenicity is controlled by an efficient immune response that operates systemically. From this and other studies, no clear-cut patterns emerged which enable the prediction of the importance of site of inoculation in the growth of a particular tumor. Neither antigenicity nor growth rate correlate with the effect of injection site on tumor growth. A balance between the host''s ability to respond to the tumor and the tumor''s ability to proliferate determines the outcome of a particular host-tumor interaction.