EFFECTS OF AN INTRAVENOUS INJECTION OF TETRACOSACTID ON PLASMA CORTICOSTEROID AND TESTOSTERONE LEVELS IN UNSTRESSED MALE RABBITS

Publisher Website
Google Scholar
Abstract
Tetracosactide administration into male rabbits, fitted with permanently indwelling jugular catheters, resulted in a rapid rise of plasma corticosteroids and plasma testosterone. Corticosteroid concentrations were significantly elevated at 40 and 60 min and testosterone concentrations 20 min after the i.v. injection of tetracosactide (2.5, 5.0 and 10.0 .mu.g/kg body wt), compared to pre-treatment levels. Corticosteroid values in plasma were elevated as long as 120 min after tetracosactide injection. Testosterone levels were lower at 60-120 min after tetracosactide injection than corresponding pre-treatment values. These differences were not significant. At the doses used, no tetracosactide dose-dependent corticosteroid or testosterone release could be found. Apparently, testosterone release is only dependent upon basal plasma levels, but not upon the dose of tetracosactide applied. Tetracosactide may facilitate an increase or decrease of testosterone concentration in plasma in the buck depending upon the time elapsing between tetracosactide injection and blood withdrawal.

This publication has 9 references indexed in Scilit: