Genetic polymorphism of coagulation factor XIII B subunit in the Japanese population: description of three new rare alleles

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Abstract
Polyacrylamide gel isoelectric focusing (PAGIEF) of neuraminidase-treated EDTA plasma samples followed by electroblotting with enzyme immunoassay was performed to further investigate coagulation factor XIII B subunit (FXIII B) polymorphism. In 435 Japanese subjects PAGIEF patterns of FXIII B were classified into five common and three rare allotypes. This suggested that the FXIIIB*2 allele existed in the Japanese population in the same manner as in Caucasians. Three new rare allotypes were considered to be controlled by three rare alleles which were designated FXIIIB*13, FXIII B*14 and FXIIIB*15, respectively. The gene frequencies calculated from 435 Japanese subjects were FXIIIB*1=0.2977, FXIIIB*2=0.0184, FXIIIB*3=0.6805, FXIIIB*13= 0.0011, FXIIIB*14=0.0011, and FXIIIB*15=0.0011, respectively.