Preliminary evidence that thrombin may mimic a naturally occurring proteinase in cultured cells
- 1 November 1981
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 1 (11) , 881-884
- https://doi.org/10.1007/bf01114822
Abstract
A neutral proteinase was purified from the membranes of human leukocytes. Antibodies to this enzyme inhibit its proteolytic activity, and inhibit the growth of cultured human fibroblasts. This growth inhibition is apparently reversed by added thrombin.This publication has 11 references indexed in Scilit:
- Methods for growth of cultured cells in serum-free mediumAnalytical Biochemistry, 1980
- Thrombin-stimulated cell division involves proteolysis of its cell surface receptorNature, 1979
- Proteases stimulate proliferation of human fibroblastsJournal of Cellular Physiology, 1977
- Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.The Journal of cell biology, 1976
- Loss of a critical neutral protease in ageing WI-38 cellsNature, 1976
- AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSESThe Journal of Experimental Medicine, 1973
- Plasminogen: Purification from Human Plasma by Affinity ChromatographyScience, 1970
- Proteolytic Enzymes Initiating Cell Division and Escape from Contact Inhibition of GrowthNature, 1970
- Characteristics of a Human Diploid Cell Designated MRC-5Nature, 1970
- Separation of White Blood CellsNature, 1964