Inhibition of insulin receptor binding by dimethyl sulfoxide

• 1 February 1979
• journal article
• research article
• Published by Elsevier in Biochimica et Biophysica Acta (BBA) - General Subjects
• Vol. 582  (3) , 486-495
• https://doi.org/10.1016/0304-4165(79)90139-9

Abstract

Keywords

• INSULIN
• RECEPTOR BINDING
• DIMETHYL SULFOXIDE
• (NEGATIVE COOPERATIVITY)
• ME2SO
• HEPES
• 4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULFONIC ACID
• B/F
• BOUND/FREE
• TOTAL CONCENTRATION OF RECEPTOR SITES PER CELL
• AVERAGE AFFINITY
• LIMITING HIGH AFFINITY STATE
• LIMITING LOW AFFINITY STATE