Formation of Multilayered Vesicles from Water/Organic-Solvent (W/O) Emulsions: Theory and Practice
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 03 (1) , 23-34
- https://doi.org/10.1023/A:1016316730560
Abstract
Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the Eratio, was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.This publication has 20 references indexed in Scilit:
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