Tricyclic Antidepressant Poisoning
- 9 December 1974
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 230 (10) , 1405-1407
- https://doi.org/10.1001/jama.1974.03240100023020
Abstract
Two patients with coma, choreoathetoid movements, and myoclonus were found to be poisoned with tricyclic antidepressants. Physostigmine salicylate, a centrally active anticholinergic agent, promptly reversed the neurologic abnormalities. It appears to be the drug of choice in tricyclic antidepressant poisoning as well as in treating classical anticholinergic intoxication. It is relatively safe and can be used as a diagnostic test for suspected poisoning from these agents. These cases also support the cholinergic deficiency/dopaminergic excess hypothesis of chorea. (JAMA230:1405-1407, 1974)Keywords
This publication has 10 references indexed in Scilit:
- The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neuronsNeuropharmacology, 1971
- Desipramine (DMI): Effect on the levels of acetylcholine (ACh) in whole brain and in striatum of ratsEuropean Journal of Pharmacology, 1971
- Effect of Drugs on Amines in the CNSAnnual Review of Pharmacology, 1971
- A Pharmacologic Analysis of Huntington’s ChoreaEuropean Neurology, 1970
- Acute Poisoning by Tricyclic Antidepressants: Clinical Features and Management of 100 PatientsClinical Toxicology, 1969
- Imipramine affects dopamine uptake by rat brainJournal of Pharmacy and Pharmacology, 1968
- Effect of imipramine, physostigmine and amphetamine on the electrical activity of the brain in the catPsychopharmacology, 1968
- Delayed death in imipramine poisoning.BMJ, 1967
- The effects of psychotropic drugs on the cholinergic and adrenergic systemInternational Journal of Neuropharmacology, 1964
- Erfahrungen mit L-Dopa in der Therapie des ParkinsonismusEuropean Neurology, 1963