Liver Transplantation in Rats Using Small-for-Size Grafts
Open Access
- 1 March 2001
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 136 (3) , 280-285
- https://doi.org/10.1001/archsurg.136.3.280
Abstract
THE MAJOR concern of adult-to-adult living donor liver transplantation is the adequacy of the size of the graft.1-3 Harvesting a larger graft poses a higher risk for the living donor.4 On the other hand, a small-for-size graft may not only be functionally inadequate for the recipient, but will also sustain injury characterized by cholestasis and histological features of ischemia after implantation.3 The exact mechanism leading to injury of a small-for-size graft after liver transplantation remains unknown. It has been suggested that excessive portal flow secondary to relative portal hypertension may be the cause and that portal decompression may improve graft survival.5 The aim of the present study is to investigate the changes in portal hemodynamics and their correlation with morphological changes of small-for-size grafts on light microscopy and electron microscopy in a rat liver transplantation model.Keywords
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