The Serological Response of Cotton Rats and Monkeys to Poliomyelitis Virus
Open Access
- 1 December 1951
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 67 (6) , 463-470
- https://doi.org/10.4049/jimmunol.67.6.463
Abstract
Summary: The serological response of cotton rats and monkeys to Lansing poliomyelitis virus was studied. A specific complement fixing antigen was prepared from cotton rat nerve tissues infected with Lansing strain poliomyelitis virus. In the course of immunization, cotton rats developed a rapid rise and decline of complement-fixing antibodies; however, the neutralizing antibody developed quickly and remained elevated. The antigen failed to demonstrate complement-fixing antibodies in immunized monkeys, although the latter animals developed neutralizing antibodies.Keywords
This publication has 1 reference indexed in Scilit:
- A Complement-Fixation Test for Poliomyelitis VirusExperimental Biology and Medicine, 1950