Derivative spectrophotometric determination of clemastine fumarate in pharmaceutical preparations
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 113 (7) , 1137-1138
- https://doi.org/10.1039/an9881301137
Abstract
A simple and rapid ultraviolet spectrophotometric assay procedure is described for the determination of clemastine fumarate. The proposed method is based on direct measurement of the second-derivative spectra of samples obtained by dilution with methanol-hydrochloric acid solution. The method has been successfully applied to the determination of this drug in tablets, syrup and ampoules. The results were in good agreement with the official high-performance liquid chromatographic (HPLC) method.Keywords
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