Myo-inositol transport through the blood-brain barrier
- 1 August 1988
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 13 (8) , 785-787
- https://doi.org/10.1007/bf00971603
Abstract
The unidirectional transport of [3H]myo-inositol across cerebral capillaries, the anatomical locus of the blood-brain barrier, was measured using an in situ rat brain perfusion technique. Myo-inositol was transported across the blood-brain barrier by a low capacity, saturable system with a one-half saturation concentration of ∼0.1 mM. The permeability surface-area product was 6.2×10−5S−1 with a myo-inositol concentration of 0.02 mM in the perfusate. The myo-inositol stereoisomer scyllo-inositol but not (+)-chiro-inositol (both 1 mM) inhibited myo-inositol transfer through the blood-brain barrier. These observations provide evidence that myo-inositol is transferred through the blood-brain barrier by simple diffusion and a stereospecific, saturable transport system.This publication has 8 references indexed in Scilit:
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