Effect of chronic drug treatment on intestinal membrane transport of 14C‐l‐DOPA

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Abstract
1 . By the use of the everted jejunal sac it was shown that chronic oral treatment of rats with various drugs can either increase or decrease the mucosal transport of 14C-l-DOPA or alter its serosal/tissue ratio. 2 . 14C-l-DOPA transport was significantly increased in rats that were chronically treated with l-DOPA and diminished in those that were treated with chlorpromazine and phenobarbitone. 3 . Chronic treatment with amantadine and neomycin did not affect 14C-l-DOPA intestinal transport, although direct addition of amantadine to the medium, significantly increased 14C-l-DOPA transport in everted sacs of non-treated rats. Addition of neomycin directly to the medium did not affect 14C-l-DOPA transport. 4 . The possible mechanisms of these findings and their clinical significance are discussed.