Systemic absorption of miconazole from the vagina

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Abstract
The serum concentrations of miconazole were measured in 11 healthy adult females for 72 hours following a single 1200 mg vaginal pessary. The mean peak serum miconazok concentration was 10.4 ug/1 and the mean elimination half life was 56.8 h. The mean area under the serum concentration time curve was 967 μg/I.h. The calculated mean systemic bioavailability of the vaginal pessary was 1.4%. There was large intersubject variation in serum miconazole pharmacokinetics. This formulation may provide effective single dose treatment for vaginal candidosis.

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