Bone marrow ribonucleic acid polymerase. Effect of testosterone on nucleotide incorporation into nuclear RNA
Open Access
- 1 November 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 3 (11) , 3077-3086
- https://doi.org/10.1093/nar/3.11.3077
Abstract
The incorporation of 3H-UTP into RNA by isolated rat bone marroui nuclri is stimulated by testosterone. This effect is hormone and tissue specific. Using α-amanitine and different ionic strenght conditions it was found that testosterons enhances preferentially RNA polymerase I activity. The sedimentation pattern of RNA isolated from bone marrow nuclei shows that the synthesis of RNA species within the 14–30 S range is mainly stimulated by the hormoneKeywords
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