Disulfide bridges in human complement component C3b
- 2 January 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 315 (1) , 85-90
- https://doi.org/10.1016/0014-5793(93)81139-q
Abstract
The disulfide bridges of human complement component C3b, derived from C3 by removal of the 77‐residue C3a, have been determined. The 10 bridges are Cys537‐Cys794, Cys605‐Cys640, Cys851‐Cys1491, Cys1079‐Cys1169, Cys1336‐Cys1467, Cys1367‐Cys1436, Cys1448‐Cys1489, Cys1496‐Cys1568, Cys1515‐Cys1639, and Cys1615‐Cys1624. Including the 3 bridges in C3a (Cys670‐Cys698, Cys672‐Cys705, and Cys685‐Cys706) previously determined by high‐resolution X‐ray crystallography [Hoppe‐Seyler's Z. Physiol. Chem. 361 (1980) 1389‐1399] all disulfide bridges of C3 are localized. C3 and the strongly related C4 and C5 are members of the α2‐macroglobulin superfamily. The predicted bridge patterns of C4 and C5 are discussed and compared with that of α2‐macroglobulin.Keywords
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