Valiolamine, a new .ALPHA.-glucosidase inhibiting aminocyclitol produced by Streptomyces hygroscopicus.

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Abstract
Valiolamine, a new aminocyclitol, was isolated from the fermentation broth of S. hygroscopicus, subsp. limoneus and its structure was determined to be (1(OH),2,4,5/1,3)-5-amino-1-C-(hydroxymethyl)-1,2,3,4-cyclohexanetetrol. Valiolamine had more potent .alpha.-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase than valienamine, validamine and hydroxyvalidamine, which were reported as building blocks of validamycins and microbial oligosaccharide .alpha.-glucosidase inhibitors. Valienamine, validamine and hydroxyvalidamine were isolated from the fermentation broth.

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