ANTAGONISM OF SOME CONTRACTILE RESPONSES TO PROSTAGLANDINS BY CYPROHEPTADINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 240  (2) , 203-213
Abstract
Antagonism of the contractile responses to PG[prostaglandin]E1 and PGF2.alpha., by cyproheptadine on isolated rat stomach strip, rabbit uterus, guinea-pig ileum and rabbit jejunum is documented. Cyproheptadine blocks the responses to PGE1, PGF2.alpha., acetylcholine, 5-hydroxytryptamine in extremely small concentrations varying from 10 ng to 1 .mu.g/ml. The blockade is persistant, provided the exposure is prolonged. It does not antagonize the responses of adrenaline [epinephrine] on guinea-pig seminal vesicle. Polyphloretine phosphate was used in the concentration of 2.5 to 100 .mu.g/ml on the rat stomach strip, rabbit jejunum and rabbit uterus; it did not produce any blockade of contractile responses to PG. Cyproheptadine nonspecifically antagonized the responses to acetylcholine, 5-hydroxytryptamine, PGE1 and PGF2.alpha. in extremely small concentrations.

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