Improved Diagnosis of Pleural Tuberculosis Using the Microscopic-Observation Drug-Susceptibility Technique
Open Access
- 15 March 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 46 (6) , 909-912
- https://doi.org/10.1086/527447
Abstract
Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs. 51%; time to diagnosis, 11 days vs. 24 days; P<.001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.Keywords
This publication has 12 references indexed in Scilit:
- Diagnosis and Treatment of Tuberculous Pleural Effusion in 2006Chest, 2007
- TUBERCULOSIS MORTALITY, DRUG RESISTANCE, AND INFECTIOUSNESS IN PATIENTS WITH AND WITHOUT HIV INFECTION IN PERUThe American Journal of Tropical Medicine and Hygiene, 2006
- Microscopic-Observation Drug-Susceptibility Assay for the Diagnosis of TBNew England Journal of Medicine, 2006
- Evaluation of Polymerase Chain Reaction for Detection of Mycobacterium tuberculosis in Pleural FluidChest, 2001
- Evaluation of Polymerase Chain Reaction, Adenosine Deaminase, and Interferon-γ in Pleural Fluid for the Differential Diagnosis of Pleural TuberculosisChest, 2000
- Tuberculous PleurisyArchives of internal medicine (1960), 1998
- Hyperendemic Pulmonary Tuberculosis in a Peruvian ShantytownAmerican Journal of Epidemiology, 1998
- The Optimal Number of Pleural Biopsy Specimens for a Diagnosis of Tuberculous PleurisyChest, 1997
- Rapid diagnosis of pleural tuberculosis by polymerase chain reaction.American Journal of Respiratory and Critical Care Medicine, 1995
- A comparative study of the polymerase chain reaction and conventional procedures for the diagnosis of tuberculous pleural effusionTubercle and Lung Disease, 1992