Rat yolk‐sac antigen‐2 defined by monoclonal antibodies

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Abstract
The distribution of the rat yolk‐sac antigen‐2 (Rat YSA‐2) as defined by a monoclonal antibody raised against rat yolk‐sac carcinoma cells is described. The antigen is present on rat yolk‐sac carcinoma, on parietal yolk‐sac endoderm and on the epithelium of fetal and adult gut and of the adult proximal kidney tubules. It is not present on a variety of rat tumors other than yolk‐sac carcinomas and not detectable on preimplantation and post‐implantation embryos. Rat YSA‐2 differs from YSA‐1, other stage‐specific embryonic antigens, basement membrane antigens, intestinal and tubular antigens.