Elevated Serum Pepsinogen I: A Genetic Marker for Duodenal-Ulcer Disease

11 January 1979

journal article
Published by Massachusetts Medical Society in New England Journal of Medicine

Vol. 300 (2) , 89
https://doi.org/10.1056/nejm197901113000211

Abstract

It has long been suspected that genetic factors play an important part in duodenal-ulcer disease because the incidence is increased among first-degree relatives.¹ However, until now, no strong genetic marker for the disease had been identified. It has been known that patients with duodenal ulcer have an increased frequency of blood Group O and of the nonsecretor status of ABH antigens in saliva, but these associations are weak. Edwards² calculated that the ABO locus contributed about 1 per cent of the total variance in duodenal ulcer, and secretor status about 1.5 per cent.In this issue of the Journal, . . .

Keywords

SALIVA
WORDS APPEAR
NO ABSTRACT
LOS ANGELES
DUODENAL ULCER
DISEASE BECAUSE THE INCIDENCE
GENETIC MARKER

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