Mutagenicity tests of fabric‐finishing agents in salmonella typhimurium: Fiber‐reactive wool dyes and cotton flame retardants
- 1 January 1980
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 2 (3) , 405-418
- https://doi.org/10.1002/em.2860020311
Abstract
Thirty-nine fabric-finishing agents were tested for mutagenic activity in Salmonella typhimurium. Twenty-four fiber-reactive wool dyes and three acid dyes (not fiber-reactive) were screened by spot tests in strains TA100, TA98, TA1535, and TA1537. Among these dyes, seven bromoacrylamide dyes and one vinyl sulfone dye were mutagenic. Additionally, one of the three acid dyes was mutagenic in spot tests. The mutagenicity of the acid dye was due to an impurity or breakdown product rather than to the dye itself; the origin of the activities of the other dyes is unknown. No mutagenicity was observed among five chlorotriazine or four sulfonyl-ethane sulfonic acid dyes. Eight phosphorus-containing flame retardants (phosphonium, phosphine, phosphine oxide, and phosphonic acid derivatives) and methyl-N-methylolcarbamate, which is employed to obtain a flame-retardant finish on cotton, were tested for mutagenicity in strains TA100, TA98, TA1535, and TA1537, using quantitative incorporation assays. All were nonmutagenic. Two of three bromoalkyl-substituted triazine flame retardants were mutagenic in strains TA100 and TA1535. It is unknown whether this activity is due to impurities or to the parent compound. The flame retardants tested were either in actual commercial use or in experimental development for potential commercial processes. These results indicate the need for early testing of potential fabric-finishing agents and processes.Keywords
This publication has 13 references indexed in Scilit:
- Identifying Environmental Chemicals Causing Mutations and CancerScience, 1979
- Another Flame Retardant, Tris-(1,3-Dichloro-2-Propyl)-Phosphate, and Its Expected Metabolites Are MutagensScience, 1978
- Cytogenetic and other effects of the chemosterilants tepa, metepa, apholate and hempa in insects (a review)Mutation Research/Reviews in Genetic Toxicology, 1978
- Flame-Retardant Additives as Possible Cancer HazardsScience, 1977
- Tris(2,3-Dibromopropyl) Phosphate: Mutagenicity of a Widely Used Flame RetardantScience, 1977
- Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.Proceedings of the National Academy of Sciences, 1975
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- REACTIONS OF PROTEINS WITH ETHYL VINYL SULFONE*International Journal of Peptide and Protein Research, 1975
- Mutagenicity of Trimethylphosphate in MiceScience, 1970
- Some Chemical and Physical Factors Influencing Flame RetardancyTextile Research Journal, 1970