The DEBR rat: an animal model of human alopecia areata
- 1 August 1991
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 125 (2) , 94-100
- https://doi.org/10.1111/j.1365-2133.1991.tb06054.x
Abstract
The Dundee experimental bald rat (DEBR) is reported as a model for human alopecia areata. Parallels with human alopecia areata were observed in relation to the gradual and patchy loss of hair and the penetration of both pelage and vibrissa follicles by mononuclear cells. In particular, the apparent disruption of the follicles within the precortical region of the epidermal component and consequent alterations of normal geometrical relationships between dermal and epidermal components relate directly to similar studies on human alopecia areata. In comparison with other previously described hypotrichotic rodent mutants, the DEBR rat exhibits a unique mechanism of hair loss which may provide important information regarding the pathomechanism of human alopecia areata.Keywords
This publication has 24 references indexed in Scilit:
- Ocular and testicular abnormalities in alopecia areataArchives of Dermatology, 1982
- Topical treatment of alopecia areataArchives of Dermatology, 1981
- Alopecia AreataPublished by Elsevier ,1979
- An athymic nude mutation in the ratNature, 1978
- Alopecia AreataArchives of Dermatology, 1963
- The Human Hair Cycle11From the Department of Dermatology of the University of Pennsylvania, Philadelphia, Pa. This research was supported by U.S. Army Research Contract DA 49-007-MD-154.Journal of Investigative Dermatology, 1959
- A study of the post-natal development of the skin and hair of the mouseThe Anatomical Record, 1941
- “RHINO”, AN ALLELE OF HAIRLESS IN THE HOUSE MOUSEJournal of Heredity, 1940
- The external expression and comparative dermal histology of hereditary hairlessness in mammalsCell and tissue research, 1932
- HAIRLESS MICEJournal of Heredity, 1926