Antagonism of Anticonvulsants by Adrenergic Blocking Agents

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Abstract
Summary Alpha and beta adrenergic receptor blocking agents were tested for their ability to block the anticonvulsant effect of diphenylhydantoin, acetazolamide and chlor-diazepoxide. The anticonvulsant effect of acetazolamide was significantly antagonized by all the blocking agents but DCI, while the anticonvulsant activity of diphenylhydantoin and chlordiazepoxide was only antagonized by dibenzyline. The blockade of the anticonvulsant effect of acetazolamide by adrenergic blocking agents supports the hypothesis that catechola mines are involved in the anticonvulsant effect of this compound.