Rapid Genotypic Detection of Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis Directly in Clinical Specimens
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 44 (7) , 2605-2608
- https://doi.org/10.1128/jcm.00752-06
Abstract
A multiplex PCR DNA strip assay (Genotype MTBDR) designed to detect rifampin ( rpoB ) and high-level isoniazid ( katG ) resistance mutations in Mycobacterium tuberculosis isolates was optimized for clinical specimens. Successful genotypic results were achieved with 36 of 38 (95%) smear-positive respiratory specimens, allowing rapid therapeutic adjustments in transmittable drug-resistant tuberculosis.Keywords
This publication has 20 references indexed in Scilit:
- Rifampicin and isoniazid resistance mutations in Mycobacterium tuberculosis strains isolated from patients in Kazakhstan.2005
- Simple, phage-based (FASTPplaque) technology to determine rifampicin resistance of Mycobacterium tuberculosis directly from sputum.2004
- Rapid detection of rifampicin susceptibility of Mycobacterium tuberculosis in sputum specimens by mycobacteriophage assay.2004
- Direct Detection of Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis in Auramine-Rhodamine-Positive Sputum Specimens by Real-Time PCRJournal of Clinical Microbiology, 2004
- The global situation of MDR-TBTuberculosis, 2003
- Detection and drug-susceptibility testing of M. tuberculosis from sputum samples using luciferase reporter phage: comparison with the Mycobacteria Growth Indicator Tube (MGIT) systemDiagnostic Microbiology and Infectious Disease, 2003
- Rapid differentiation between clinically relevant mycobacteria in microscopy positive clinical specimens and mycobacterial isolates by line probe assayDiagnostic Microbiology and Infectious Disease, 2002
- Evaluation of a New Commercial Assay for Diagnosis of Pulmonary and Nonpulmonary TuberculosisEuropean Journal of Clinical Microbiology & Infectious Diseases, 2002
- Detection of Rifampin Resistance in Mycobacterium tuberculosis in a Single Tube with Molecular BeaconsJournal of Clinical Microbiology, 2001
- Molecular genetic basis of antimicrobial agent resistance inMycobacterium tuberculosis: 1998 updateTubercle and Lung Disease, 1998