Influence of the −675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden

1 July 2000

journal article
research article
Published by Wiley in British Journal of Haematology

Vol. 110 (1) , 135-138
https://doi.org/10.1046/j.1365-2141.2000.02152.x

Abstract

Elevated plasminogen activator inhibitor 1 (PAI‐1) levels are associated with venous thromboembolism, although their significance is unclear. PAI‐1 levels are influenced by a PAI‐1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI‐1 activity. We investigated whether the 4G allele influenced thrombotic risk by studying 99 symptomatic factor V (FV) Leiden heterozygotes and 99 healthy subjects. The 4G allele was more prevalent among cases than among healthy subjects (χ² = 8·00, P = 0·005) and the odds ratio (OR) for thrombosis associated with either heterozygosity or homozygosity for the 4G allele was 2·43 (P = 0·011). We conclude that carriership of the 4G allele was more prevalent in patients who already carried factor V Leiden than in control subjects without factor V Leiden.

Keywords

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