EFFECT OF LIPID A AND FATTY ACIDS ON TRANSPORT ACTIVITIES OF MEMBRANE VESICLES FROM ESCHERICHIA COLI

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Abstract
The effect of lipid A from Salmonella typhimurium and various fatty acids on the transport activities of membrane vesicles from E. coli was investigated. Lipid A and fatty acids severely inhibited the accumulation of succinate or serine which are coupled to electron transport; glucose transport, which was catalyzed by the phosphotransferase system, was stimulated slightly by these compounds. Lipid A and myristic acid may act at the same site in the succinate transport system, since no additive effect was observed in the inhibition even at a low concentration of these compounds. Lipid A and myristic acid caused the efflux of pre-loaded 14C-succinate in the membrane vesicles.