Active Host Resistance for Transplant Syngeneic C57BL Lymphomas

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Abstract
Quantitative experiments on the state of relative host resistance built up in inbred C57BL mice using the recently adapted and long transplanted syngeneic lymphoma were carried out. These animals are skin-graft-compatible when of the same sex. A five-to tenfold increase in TD50 was produced for the long transplanted LSA tumor by serial challenge survival. However, pretreatment with radiation-treated cells was ineffective. A newly induced LSY lymphoma produced in C57BL mice a fivefold rise in resistance by serial exposure (3 × ) of normal recipients to radiation-treated cells. Likewise, a fivefold suppression in host resistance was achieved by a 400-R whole-body X-radiation dose. Thus, for the recently adapted lymphoma, pretreatment with radiated cells was an effective immunogenic stimulant. For a reference L2 lymphoma of A mice in LAF1 mice, a 27-fold increase in resistance was obtained after several challenges. Resistance was more effectively produced in animals by using serial sublethal tumor challenge with viable tumor cells. The resistance was tumor-specific, but was weak. For the mouse lymphomas studies, viable cells rather than radiated cells represented a far more potent stimulant of host resistance, and was produced more readily with the new rather than with the old transplant lymphomas.

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