Crown Ether Catalysis in the Synthesis of Cyanohydrin Derivatives

1 March 1983

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 13 (5) , 403-409
https://doi.org/10.1080/00397918308066996

Abstract

Carbonyl compounds react with cyanide ion under phase transfer catalysis (18-crown-6) to give cyanohydrin anions which are trapped by acid chlorides, anhydrides or alkylating agents to give cyanohydrin derivatives.

Keywords

This publication has 5 references indexed in Scilit:

A new synthesis of cyanohydrin esters
The Journal of Organic Chemistry, 1981
Phase-transfer catalyzed formation of cyanohydrin ethers and acetates
Canadian Journal of Chemistry, 1977
Synthesis of small rings via the protected cyanohydrin method.
Tetrahedron Letters, 1975
Chemistry of naked anions. III. Reactions of the 18-crown-6 complex of potassium cyanide with organic substrates in aprotic organic solvents
The Journal of Organic Chemistry, 1974
The Preparation of Nitriles.
Chemical Reviews, 1948