Combination of cis‐platinum, oncovin, and bleomycin (cob) prior to surgery and/or radiotherapy in advanced untreated epidermoid cancer of the head and neck

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Abstract
A prospective study was carried out to investigate the effectiveness and feasibility of two courses of combination therapy with COB every three weeks prior to surgery and/or radiotherapy in 70 patients with advanced untreated epidermoid cancer of the head and neck. Of 65 patients evaluable after two courses of chemotherapy, 16 had a complete remission (CR) and 36 had a partial remission (PR; > 50% — < 100%) for a total major response rate of 80%.