VASOMOTOR EFFECTS OF BLOOD IN PATIENTS WITH HYPERTENSION AND ANIMALS WITH EXPERIMENTAL HYPERTENSION

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Abstract
Cross transfusion of blood between subjects with hypertension and patients with normal blood pressures showed no significant change in either subject even when the amt. of blood exchanges was 2000 cc. Whole, undiluted blood plasma from a patient with hypertension was perfused through the isolated rabbit''s ear and in the majority of instances the plasma removed from the hypertensive individual was relatively depressor; but the blood of a patient with adrenal pheochromocytoma collected during a paroxysm of hypertension and similarly tested showed a marked pressor effect due to presence of circulating epinephrin (which disappeared when tumor was removed). If organs of hypertensive dogs were perfused with blood from normal and hypertensive dogs, it was shown that there was no pressor effect in either case. There was no pressor effect of renal vein blood. Tonus and the ability to dilate and constrict were present in vessels of normal and hypertensive animals deprived of both central vasomotor nervous connections and circulating blood. 23 out of 31 instances, the blood from hypertensive patients showed a depressor effect which made it unlikely that hypertension was due to directly acting vasoconstrictor substances as epinephrine or pituitrin. The cause of arterial tonus was not known but it was not nervous nor due to direct effect of pressor substance.

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