The role of ribosomal RNA in the control of ribosomal protein synthesis.
- 1 November 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (5) , 1465-1470
- https://doi.org/10.1073/pnas.54.5.1465
Abstract
A model of control is proposed, in which (1) the synthesis of ribosomal protein is directed by "preribosomal" RNA, (2) the rate of protein synthesis is proportional to the cellular concentration of this RNA, and (3) RNA is removed from the "preribosomal" pool in proportion to the amount of protein synthesized, with the RNA and the newly synthesized protein combining ultimately to form complete ribosomes. When applied to an experimental system in which RNA synthesis is abruptly inhibited while protein synthesis is allowed to continue, the model correctly predicts the observed experimental results.This publication has 4 references indexed in Scilit:
- Formation of ribosomes by a “relaxed” mutant of Escherichia coliJournal of Molecular Biology, 1965
- Selective synthesis of ribosomal protein during recovery from unbalanced growthBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965
- Fate of the ribosomal RNA produced by a “relaxed” mutant of Escherichia coliJournal of Molecular Biology, 1964
- Dependency on Medium and Temperature of Cell Size and Chemical Composition during Balanced Growth of Salmonella typhimuriumJournal of General Microbiology, 1958