Human X (Mouse X Human) Hybridomas Stably Producing Human Antibodies
- 1 January 1983
- journal article
- research article
- Published by Mary Ann Liebert Inc in Hybridoma
- Vol. 2 (4) , 361-367
- https://doi.org/10.1089/hyb.1983.2.361
Abstract
A method is described for constructing mouse heterohybridomas producing human monoclonal antibody with a high stability. The essence of the method is the use of a nonsecretor mouse X human hybridoma which has been made 8-azaguanine resistant as a fusion parent for construction of (mouse X human) X human hybridomas. The production of four human anti-influenza antibodies is described. The cells have now been maintained for more than 22 months in culture.This publication has 13 references indexed in Scilit:
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