Synthesis of Acyclic Nucleotide Analogues Derived from 6-(sec- or tert-Alkyl)purines via Coupling of 6-Chloropurine Derivatives with Organocuprates

1 January 1998

journal article
Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications

Vol. 63 (12) , 2065-2074
https://doi.org/10.1135/cccc19982065

Abstract

Coupling of 9-[2-(diisopropyloxyphosphonylmethoxy)ethyl]-6-chloropurine (23) (and (R)-9-[2-(diisopropyloxyphosphonylmethoxy)propyl]-6-chloropurine (24), respectively) with organocuprates derived from Grignard reagents afforded after deprotection 6-(sec- or tert-alkyl) substituted phosphonates 31-36. As a model a series of 6-(sec- or tert-alkyl)purines 2-12 was also prepared.

Keywords

SEC
DIISOPROPYLOXYPHOSPHONYLMETHOXY
KEYWORDS
CHLOROPURINE
DEPROTECTION
TERT ALKYL
PURINES
PHOSPHONATES

This publication has 0 references indexed in Scilit: