CD3‐Induced T‐Cell Proliferation and Interleukin‐2 Secretion is Modulated by the CD45 Antigen

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Abstract
In the present study we have investigated the effect of CD45, C D45RA and CD45RO monoclonal antibodies (MoAbs) on the CD3 receptor‐mediated proliferation of human T lymphocytes. It is shown that CD3‐induced proliferation of purified resting T cells and quiescent T lymphoblasts (QT L) is promoted via all of the investigated CD45‐associatcd epitopes. It is also shown that the CD45 molecules are required to be cross‐linked for costimulation. The MoAbs enhance the interleiikin‐2 (IL‐2) production of CD3‐stimulated QTL. The elevation of the IL‐2 production correlates with the increase in CD3‐inducod cell proliferation suggesting that the CD45‐driven regulation of T lymphocyte activation is linked to the IL‐2 pathway.