Effects of Administration of Cobalt Chloride and Cobalt Protoporphyrin on δ-Aminolevulinate Synthase in Rat Liver1
- 1 October 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 84 (4) , 997-1000
- https://doi.org/10.1093/oxfordjournals.jbchem.a132215
Abstract
Cobalt protoporphyrin inhibited the drug-induced increase of δ-aminolevulinate synthase as well as its transfer from the cytosol fraction to the mitochondria in rat liver in a similar way to protoheme. Cobalt chloride given to animals in a large dose exhibited similar effects. Cobalt protoporphyrin was isolated from the liver of rats treated with cobalt chloride. The observed regulatory effects of cobalt chloride with respect to the induction and the intracellular translocation of δ-aminolevulinate synthase may be mediated by cobalt protoporphyrin synthesized in vivo.This publication has 3 references indexed in Scilit:
- Studies on the mechanism of the conversion of cytosol δ-aminolevulinic acid synthase to the mitochondrial enzyme in the liver of the allylisopropylacetamide-treated ratArchives of Biochemistry and Biophysics, 1976
- δ-Aminolevulinate Synthetases in the Liver Cytosol Fraction and Mitochondria of Mice Treated with Allylisopropylacetamide and 3, 5-Dicarbethoxy-1, 4-dihydrocollidine1The Journal of Biochemistry, 1976
- Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.Proceedings of the National Academy of Sciences, 1976