Significance of Hageman Factor (Coagulation Factor XII) for Neutrophil Locomotion and Chemotaxis
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 55 (1-6) , 309-313
- https://doi.org/10.1159/000231941
Abstract
Neutrophils separated from Hageman factor-deficient blood exhibit normal random and directional locomotion. No defect in cytotaxin formation could be demonstrated in Hageman factor-deficient plasma, nor did kallikrein inhibitor interfere with the chemotactic activity of normal immune complex-activated human plasma. The results suggest that the chemotactic activity which is detectable in unfractionated human plasma is not derived from Hageman factor-dependent pathways.This publication has 1 reference indexed in Scilit:
- Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory responseJournal of Allergy and Clinical Immunology, 1975