CYCLOSPORIN-A APPLIED TOPICALLY TO THE RECIPIENT EYE INHIBITS CORNEAL GRAFT-REJECTION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 45  (1) , 173-177
Abstract
Corneal graft survival in rabbits was significantly (P < 0.001) prolonged by topical treatment to the recipient eye with cyclosporin A 1% in arachis oil applied 5 times daily for 4 wk. No graft was rejected while treatment was maintained; all grafts subsequently underwent rejection by the 64th postoperative day. All animals in a simultaneous control group in this fully masked study developed allograft reactions by the 23rd day. No local or systemic side effects attributable to cyclosporin A were observed. This apparently is the 1st report of inhibition of an allograft reaction by cyclosporin A applied topically.