Cellular Sites of Immunoglobulins

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Abstract
Immunoglobulins (Igs) in gall bladder bile were measured by radial immunodiffusion, and the distribution of Ig-containing cells in gall bladder mucosa was studied by immunofluorescence. Ig-containing cells were considerably less numerous than in the alimentary tract, although as in gastrointestinal mucosa, IgA-containing cells greatly exceeded IgM- and IgGcontaining cells. The total number of immunocytes in gall bladder mucosa was not correlated with severity of cholecystitis, except for moderately increased numbers of IgM -containing cells in empyematous gall bladders. There were, however, increased numbers of IgG- and IgM-containing cells in muscle layers of severely inflamed gall bladders. Ig levels in bile were highly variable and often bore no quantitative relationship to the number of gall bladder immunocytes. This may indicate that biliary Ig concentrations are influenced by multiple factors, such as variable contributions from the liver, transudation or absorption across inflamed mucosa, or local synthesis and secretion by the gall bladder.

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