Estimating the Number of Organisms in Quantal Assays
- 1 January 1972
- journal article
- research article
- Published by American Society for Microbiology in Applied Microbiology
- Vol. 23 (4) , 784-790
- https://doi.org/10.1128/aem.23.4.784-790.1972
Abstract
It has been demonstrated by virologists that, when procedural difficulties can be overcome and host variation can be eliminated, dosage-response data from virus assays conform with the one-particle theory of infection for both plaque counts and tissue cultures. Based on this theory, the number of virus particles from quantal virus assays can be estimated. Here a set of tables is presented from which the number of estimated particles can be obtained directly for several dilution factors and a number of dilution levels. Maximum likelihood estimation of particle counts is also illustrated using a computer program that we have prepared.Keywords
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