Infections in IFNGR-1-Deficient Children
- 1 October 1997
- journal article
- review article
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 17 (10) , 583-587
- https://doi.org/10.1089/jir.1997.17.583
Abstract
Human interferon-γ receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guérin (BCG) vaccine or environmental nontubcrculous mycobacteria (NTM). This review compares the infections found in IFNGR-1-deficient children to those in IFN-γ-deficient or IFNGR-1-deficient mice.Keywords
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