[Effect of naftidrofuryl on creatinine serum concentration and on PAH/inulin clearance in peripheral arterial occlusive diseases].

  • 1 March 1975
    • journal article
    • abstracts
    • Vol. 25  (3) , 429-31
Abstract
The effect of 200 mg 3-(1-naphthyl)-2-tetrahydrofurfurylpropionic acid beta-diethylaminoethylester (naftidrofuryl, Dusodril) administered as a single i.v. infusion, on serum creatinine was investigated in 10 patients with occlusive disease of the peripheral arteries (average age 58.6 years). In a second group of similar patients (average age 60.5 years) determinations of PAH/inulin clearance and serum creatinine were performed prior to and immediately after treatment with 400 mg naftidrofuryl per day over a period of two weeks. Creatinine concentration did not change following acute or chronic administration of naftidrofuryl; glomerular filtration rate and renal plasma flow were not affected by prolonged treatment (2 alpha less than 0.05). An obligatorily nephrotoxic effect of naftidrofuryl can therefore be ruled out.

This publication has 0 references indexed in Scilit: