Mutant Prevention Concentrations of Fluoroquinolones for Enterobacteriaceae Expressing the Plasmid-Carried Quinolone Resistance Determinant qnrA1
Open Access
- 1 June 2007
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (6) , 2236-2239
- https://doi.org/10.1128/aac.01444-06
Abstract
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1 , mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.Keywords
This publication has 22 references indexed in Scilit:
- The worldwide emergence of plasmid-mediated quinolone resistanceThe Lancet Infectious Diseases, 2006
- Common Region CR1 for Expression of Antibiotic Resistance GenesAntimicrobial Agents and Chemotherapy, 2006
- Correlation of quinolone resistance levels and differences in basal and quinolone-induced expression from three qnrA-containing plasmidsClinical Microbiology & Infection, 2006
- In Vivo Selection of Fluoroquinolone-Resistant Escherichia coli Isolates Expressing Plasmid-Mediated Quinolone Resistance and Expanded-Spectrum β-LactamaseAntimicrobial Agents and Chemotherapy, 2006
- Emergence of plasmid-mediated resistance to quinolones in EnterobacteriaceaeJournal of Antimicrobial Chemotherapy, 2005
- Association of Plasmid-Mediated Quinolone Resistance with Extended-Spectrum β-Lactamase VEB-1Antimicrobial Agents and Chemotherapy, 2005
- Emergence of Plasmid-Mediated Quinolone Resistance in Escherichia coli in EuropeAntimicrobial Agents and Chemotherapy, 2005
- Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral doseInternational Journal of Antimicrobial Agents, 2004
- Detection of the plasmid-mediated quinolone resistance determinant qnr among clinical isolates of Klebsiella pneumoniae producing AmpC-type -lactamaseJournal of Antimicrobial Chemotherapy, 2003
- The safety profile of the fluoroquinolonesClinical Therapeutics, 2000