Experimental Ascites

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Abstract
A modification of the method of producing hepatic outflow block and ascites by direct ligation of the hepatic veins was evaluated in 37 dogs. The modification consisted of inserting an externally controlled polyethylene choker around the superior hepatic vein in place of the previously used fiberglas ligature. After the animals recovered from the hepatic vein ligation the increments at 5-to 7-day intervals. All 37 dogs developed massive ascites which averaged 4.0 L. In addition, the animals developed portal hypertension with portal pressures which, at re-operation in 17 dogs, averaged 220 mm saline. At autopsy the livers in all dogs were markedly enlarged and in 2/3''s there was total hepatic outflow block with occlusion of the superior hepatic vein. Serial liver biopsies showed severe congestion, hydrops and necrosis of the hepatic parenchyma. It is concluded that this modification of the technic of hepatic vein ligation provides a controllable and gradual method of producing hepatic venous outlfow obstruction and uniformly results in massive, persistent ascites.