THE FLUORINE CONTENT OF THE THYROID GLAND IN CASES OF HYPERTHYROIDISM

23 July 1938

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 111 (4) , 300-302
https://doi.org/10.1001/jama.1938.02790300010003

Abstract

Fluorine apparently has an influence on the thyroid, but there is no agreement as to just how the gland is affected and how this effect is manifested. Houssay¹produced goiter in two white rats by giving them water from the goitrous region of Cerrillos, Argentina. This water is reported to contain fluorine. Goldemberg²produced a condition in rats which resembled cretinism by the administration of sodium fluoride. The thyroids of these rats were from five to six times as large as those of normal rats. Tolle and Maynard³and Kick and his associates⁴on the other hand could detect no enlargement of the thyroids of rats on different levels of fluorine for varying lengths of time. Cristiani⁵observed marked lesions in the thyroids of guinea pigs dying from chronic fluorine intoxication. Phillips and Lamb⁶observed a mild parenchymatousproliferation in the thyroids of rats

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