EFFECT OF CARRIER TECHNETIUM IN PREPARATION OF TC-99M HUMAN SERUM-ALBUMIN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (8) , 704-706
Abstract
Accumulation of daughter 99Tc in 99Mo-99mTc generator systems may adversely affect the preparation of certain 99mTc radiopharmaceuticals. In a study of the effect of carrier technetium on the radiochemical purity of 99mTc-human serum albumin, varying amounts of 99Tc were added to a commercially available electrolytic kit. The maximum amount of 99Tc that could be added to such a kit and still maintain radiochemical purity above 90% was about 3 .times. 1015 atoms. When kits containing 1016 99Tc atoms were electrolyzed for the conventional 42 s, the radiochemical purity was only 50.8%. When the electrolysis time was varied, electrolysis for 80 s yielded a product with greater than 90% radiochemical purity. Four solutions to the problem created by the 99Tc carrier effect are described.

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